Milbenin 12,5 mg/125 mg

Milbenin 12,5 mg/125 mg is an antiparasitic for dogs, suitable for the treatment of mixed infections with adult cestodes and nematodes sensitive to praziquantel and milbemycin oxime. It can also be used for prevention of heartworm disease if concurrent treatment against cestodes is required. Milbenin 12,5 mg/125 mg is among the veterinary drugs available without veterinary prescription (VRIJ).

Milbenin 12,5 mg/125 mg has the registration number NL 129070.

Indication

Treatment of mixed infections with adult cestodes and nematodes of the following species sensitive to praziquantel and milbemycin oxime:

  • Cestode: Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp.
  • Nematodes: Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Crenosoma vulpis, Angiostrongylus vasorum, Thelazia callipaeda

The veterinary drug may also be used for prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against cestodes is required.

Contraindication

  • Do not use in dogs weighing less than 5 kg.
  • Do not use in case of hypersensitivity to the active ingredients or any of the excipients.

Dosage

For oral use.
Recommended minimum dose: 0,5 mg milbemycin oxime and 5 mg praziquantel per kg body weight are administered once.
Administer the veterinary medicine with or after some food.

Depending on the dog's body weight, the practical dosage is as follows:

  • Weight 5-25 kg = 1 chewable tablet Milbenin 12,5 mg/125 mg chewable tablets for dogs.
  • Weight >25-50 kg = 2 chewable tablets Milbenin 12,5 mg/125 mg chewable tablets for dogs.
  • Weight >50-75 kg = 3 chewable tablets Milbenin 12,5 mg/125 mg chewable tablets for dogs.

To ensure correct dosing, body weight should be determined as accurately as possible to avoid underdosing.

When the veterinary medicine is used for the prevention of heartworm disease and at the same time requires treatment against tapeworms, the veterinary medicine may replace the monovalent veterinary medicine for the prevention of heartworm disease.

For the treatment of Angiostrongylus vasorum infections, milbemycin oxime should be administered four times at one-week intervals. It is recommended that, if concomitant treatment against cestodes is indicated, treatment with the veterinary medicinal product should be continued with the monovalent veterinary medicinal product containing only milbemycin oxime for the remaining three weekly treatments.

Administration of the veterinary medicine every four weeks in endemic areas prevents angiostrongyosis by reducing immature adult (L5) and adult parasites, where concomitant treatment against cestodes is indicated.

For treatment against Thelazia callipaeda, milbemycin oxime should be administered as 2 treatments seven days apart. If concomitant treatment against cestodes is indicated, the veterinary medicinal product may replace the monovalent veterinary medicinal product containing milbemycin oxime alone.

Composition

Per chewable tablet:

Active ingredients:
Milbemycin oxime 12,5 mg
Praziquantel 125,0 mg

White to off-white, round chewable tablets with evenly distributed brown pigmentation.

Side effects

Very rarely (<1 animal / 10,000 animals treated, including isolated reports):

  • hypersensitivity reactions
  • lethargy
  • muscle tremor, ataxia and convulsions
  • vomiting, drooling, diarrhoea and anorexia

Leaflet

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