Indication
Treatment of mixed infections with adult cestodes and nematodes of the following species sensitive to praziquantel and milbemycin oxime:
- Cestode: Dipylidium caninum, Taenia spp., Echinococcus spp., Mesocestoides spp.
- Nematodes: Ancylostoma caninum, Toxocara canis, Toxascaris leonina, Trichuris vulpis, Crenosoma vulpis, Angiostrongylus vasorum, Thelazia callipaeda
The veterinary drug may also be used for prevention of heartworm disease (Dirofilaria immitis) if concomitant treatment against cestodes is required.
Contraindication
- Do not use in dogs weighing less than 5 kg.
- Do not use in case of hypersensitivity to the active ingredients or any of the excipients.
Dosage
For oral use.
Recommended minimum dose: 0,5 mg milbemycin oxime and 5 mg praziquantel per kg body weight are administered once.
Administer the veterinary medicine with or after some food.
Depending on the dog's body weight, the practical dosage is as follows:
- Weight 5-25 kg = 1 chewable tablet Milbenin 12,5 mg/125 mg chewable tablets for dogs.
- Weight >25-50 kg = 2 chewable tablets Milbenin 12,5 mg/125 mg chewable tablets for dogs.
- Weight >50-75 kg = 3 chewable tablets Milbenin 12,5 mg/125 mg chewable tablets for dogs.
To ensure correct dosing, body weight should be determined as accurately as possible to avoid underdosing.
When the veterinary medicine is used for the prevention of heartworm disease and at the same time requires treatment against tapeworms, the veterinary medicine may replace the monovalent veterinary medicine for the prevention of heartworm disease.
For the treatment of Angiostrongylus vasorum infections, milbemycin oxime should be administered four times at one-week intervals. It is recommended that, if concomitant treatment against cestodes is indicated, treatment with the veterinary medicinal product should be continued with the monovalent veterinary medicinal product containing only milbemycin oxime for the remaining three weekly treatments.
Administration of the veterinary medicine every four weeks in endemic areas prevents angiostrongyosis by reducing immature adult (L5) and adult parasites, where concomitant treatment against cestodes is indicated.
For treatment against Thelazia callipaeda, milbemycin oxime should be administered as 2 treatments seven days apart. If concomitant treatment against cestodes is indicated, the veterinary medicinal product may replace the monovalent veterinary medicinal product containing milbemycin oxime alone.
Composition
Per chewable tablet:
Active ingredients:
Milbemycin oxime 12,5 mg
Praziquantel 125,0 mg
White to off-white, round chewable tablets with evenly distributed brown pigmentation.
Side effects
Very rarely (<1 animal / 10,000 animals treated, including isolated reports):
- hypersensitivity reactions
- lethargy
- muscle tremor, ataxia and convulsions
- vomiting, drooling, diarrhoea and anorexia
FAQ